Results:
At data cutoff (Nov 28, 2025), 32 pts with EC (26 mismatch repair proficient [pMMR], 6 MMR deficient [dMMR]) received 5 mg/kg (n=16) or 10 mg/kg (n=16) SSGJ-707 + chemo. Median SSGJ-707 tx duration was 5.6 mo (range, 0.2-13.6); 8 pts (25.0%) discontinued tx. In the evaluable population, confirmed ORR was 85.7% (12/14 pts) for the 5 mg/kg dose and 80.0% (12/15) for the 10 mg/kg dose. Results for pMMR and dMMR groups are in the Table. Median PFS, OS, and DOR were not reached for either dose. Any-grade tx-related adverse events (TRAEs) were reported in 30/32 pts (93.8%) and grade ≥3 TRAEs in 22/32 pts (68.8%). The most common TRAEs (≥40%) included neutrophil count decreased (59.4%), white blood cell count decreased (59.4%), anemia (56.3%), and platelet count decreased (56.3%). No TRAEs led to death. TRAEs led to discontinuation of SSGJ-707 in 2 pts (6.3%). Immune-related AEs occurred in 6 pts (18.8%): hypothyroidism (n=4), hyperthyroidism (n=3), and rash (n=2). VEGF-related AEs occurred in 13 pts (40.6%): blood pressure elevation (n=6), proteinuria (n=6), hemorrhage (urinary occult blood positive; n=2), perforation and fistula (n=2), and venous thrombosis (n=1).
Conclusions:
SSGJ-707 + chemo demonstrated promising efficacy with a manageable safety profile in pts with tx-naive advanced/recurrent EC, supporting further investigation of SSGJ-707 in these pts.
本文作者可以追加内容哦 !
